2024

  • Absolute quantitative and base-resolution sequencing reveals comprehensive landscape of pseudouridine across the human transcriptome

    Xu H, Kong L, Cheng J, Moussawi KA, Chen X, Iqbal A, Wing PAC, Harris JM, Tsukuda S, Embare-Buh A, Wei G, Castello A, Kriaucionis S, McKeating JA, and Song CX.

    Nature Methods (2024)

  • An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection

    Mukherji A, Jühling F, Simanjuntak Y, Crouchet E, Del Zompo F, Teraoka Y, Haller A, Baltzinger P, Paritala S, Rasha F, Fujiwara N, Gadenne C, Slovic N, Oudot MA, Durand SC, Ponsolles C, Schuster C, Zhuang X, Holmes J, Yeh M-L, Abe-Chayama H, Heikenwälder M, Sangiovanni A, Iavarone M, Colombo M, Foung SKH, McKeating JA, Davidson I, Yu M-L, Chung RT, Hoshida Y, Chayama K, Lupberger J and Baumert TF

    Nature Communications (2024)

    See this work

  • Characterisation of HBV and co-infection with HDV and HIV through spatial transcriptomics

    Cross A, Harris JM, Arb-Barnes E, Nixon C, Dhairyawan R, Hall A, Quaglia A, Issa F, Kennedy PTF, McKeating JA, Gill US, and Peppa D.

    eGastroenterology (2024)

    See this work

  • Highlights from the 2023 International Meeting on the Molecular Biology of Hepatitis B Virus

    HBV2023, Allwiess L, Cohen C, Dias J, Fumagalli V, Guo H, Harris M, Hu J, Iannacone M, sogawa M, J WJ, Kim KH, Kramvis A, Li W, Lucifora J, Muramatsu M, Neuveut C, Ploss A, Pollicino T, Protzer U, Tan A, Tanaka Y, Tu T, Tsukuda S, Thimme R, Urban S, Watashi K, Yuan Z, Yeh SH, McKeating JA, and Revill P.

    Journal of General Virology (2024)

    See this work

  • Hypoxia inducible factors inhibit respiratory syncytial virus infection by modulation of nucleolin expression.

    Zhuang X, Gallo G, Sharma P, Ha J, Magri A, Borrmann H, Harris JM, Tsukuda S, Bentley E, Kirby A, de Neck S, Yang H, Balfe P, Wing PAC, Matthews D, Harris AL, Kipar A, Stewart JP, Bailey D, and McKeating JA

    iScience (2024)

    See this work
    https://ars.els-cdn.com/content/image/1-s2.0-S2589004223028407-fx1_lrg.jpg

  • The N6-methyladenosine demethylase ALKBH5 regulates the hypoxic HBV transcriptome

    Tsukuda S, Harris JM, Magri A, Balfe P, Wing PAC, Siddiqui A, and McKeating JA.

    PLoS Pathogens (2024)

    See this work

  • Oxygen-dependent histone lysine demethylase 4 restricts hepatitis B virus replication

    Harris JM, Magri A, Faria AR, Tsukuda S, Balfe P, Wing PAC, and McKeating JA

    Journal of Biological Chemistry (2024)

    See this work

  • CTCF regulates hepatitis B virus cccDNA chromatin topology

    Dobrica MO, Varghese CS, Harris JM, Ferguson J, Magri A, Arnold R, Varnai C, Parish JL, and McKeating JA. 

    Journal of General Virology (2024)

    See this work

2023

  • ASSP2 binds to hepatitis C virus NS5A protein via an SH3 domain/PxxP motif-mediated interaction and potentiates infection

    Smirnov A, Magri A, Lotz R, Huan X, Yin C, Harris M, Osterburg O, Dötsch V, McKeating JA and Lu X.

    Journal of General Virology (2023)

    See this work

  • Hypoxia dampens innate immune signalling at early time points and increases Zika virus replication in iPSC-derived macrophages

    Schilling M, Vaughan-Jackson A, James W, and McKeating JA.

    Journal of General Virology (2023)

    See this work

  • Inhibition of salt inducible kinases reduces rhythmic HIV-1 replication and reactivation from latency

    Borrmann H, Ismed D, Kliszcak A, Borrow P, Vasudevan S, Jagannath A, Zhuang X, and McKeating JA.

    Journal of General Virology (2023)

    See this work

  • HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation

    Yang H, Sun H, Brackenridge S, Zhuang X, Wing PAC, Quastel M, Walters L, Garner L, Wang B, Yao X, Felce SL, Peng Y, Moore S, Peeters BWA, Rei M, Gomes JC, Tomas A, Davidson A, Semple MG, Turtle LCW, Openshaw PJM, Baillie JK, Mentzer A, Klenerman P, ISARIC4C Investigators, Borrow P, Dong T, McKeating JA, Gillespie GM, and McMichael AJ.

    Science Immunology (2023)

    See this work

  • Molecular components of the circadian clock regulate HIV-1 replication

    Borrmann H, Ulkar G, Kliszczak AE, Ismed D, Schilling M, Magri A, Harris JM, Balfe P, Vasuvedan S, Borrow P, Zhuang X, and McKeating JA.

    iScience (2023)

    See this work

  • An enrichment protocol and analysis pipeline for long read sequencing of the hepatitis B virus transcriptome

    Ng E, Dobrica M-O, Harris JM, Wu Y, Tsukuda S, Wing PAC, Piazza P, Balfe P, Matthews PC, Ansari MA, and McKeating JA.

    Journal of General Virology (2023)

    See this work

  • An ACAT inhibitor suppresses SARS-CoV-2 replication and boosts antiviral T cell activity

    Wing PAC, Schmidt NM, Peters R, Erdmann M, Brown R, Wang H, Swadling L, COVIDsortium Investigators, Newman J, Thakur N, Shionya K, Morgan SB, Hinks TSC, Watashi K, Bailey D, Hansen SB, Davidson AD, Maini MK, and McKeating JA.

    PLoS Pathogens (2023)

    See this work

2022

  • Direct RNA sequencing of respiratory syncytial virus infected human cells generates a detailed overview of RSV polycistronic mRNA and transcript abundance

    Donovan-Banfield I, Milligan R, Hall S, Gao T, Murphy E, Li J, Shawli GT, Hiscox J, Zhuang X, McKeating JA, Fearns R, and Matthews DA.

    PLoS One (2022)

    See this work

  • Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection

    Taylor L, Von Lendenfeld F, Ashton A, Sanghani H, Di Pretoro S, Usselmann L, Veretennikova M, Dallman R, McKeating JA, Vasudevan S, and Jagannath A.

    iScience (2022)

    See this work

  • Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model

    Wing PAC, Prange-Barczynska M, Cross A, Crotta S, Orbegozo Rubio C, Cheng X, Harris JM, Zhuang X, Johnson RL, Ryan KA, Hall Y, Carroll MW, Issa F, Balfe P, Wack A, Bishop T, Salguero FJ, and McKeating JA.

    PLOS Pathogens (2022)

    See this work

  • Time-of-Day Variation in SARS-CoV-2 RNA Levels during the Second Wave of COVID-19.

    Zhuang X, Wang W, Borrmann H, Balfe P, Matthews PC, Eyre DW, Klerman EB, and McKeating JA.

    Viruses (2022)

    See this work

  • Inflammatory Gene Expression Associates with Hepatitis B Virus cccDNA- but Not Integrant-Derived Transcripts in HBeAg Negative Disease.

    Magri A, Harris JM, D'Arienzo V, Minisini R, Jühling F, Wing PAC, Rapetti R, Leutner M, Testoni B, Baumert TF, Zoulim F, Balfe P, Pirisi M, McKeating JA.

    Viruses (2022)

    See this Work

  • Hypoxia is more than HIFs

    Harris JM, McKeating JA, and Wing PAC

    Journal of Hepatology (2022)

    See this letter

  • The role of circadian clock pathways in viral replication.

    Zhuang X, Edgar RS, and McKeating JA.

    Seminars in Immunopathology (2022)

    See this work

  • Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences.

    Lee JY, Wing PAC, Gala DS, Noerenberg M, Järvelin AI, Titlow J, Zhuang X, Palmalux N, Iselin L, Thompson MK, Parton RM, Prange-Barczynska M, Wainman A, Salguero FJ, Bishop T, Agranoff D, James W, Castello A, McKeating JA, and Davis I

    eLife (2022)

    See this work

  • Acute intermittent hypoxia drives hepatic de novo lipogenesis in humans and rodents

    Hazlehurst, JM., Lim, TR., Charlton, C., Miller, JJ., Gathercole, LL., Cornfield, T., Nikolaou, N., Harris, SE., Moolla, A., Othonos, N., Heather,LC., Marjot, T., Tyler, DJ., Carr, C., Hodson, L., Mckeating, JA., and Tomlinson, JW.

    Metabolism Open (2022)

    See this work

  • The HCV Envelope Glycoprotein Down-Modulates NF-κB Signalling and Associates With Stimulation of the Host Endoplasmic Reticulum Stress Pathway.

    McKay LGA, Thomas J, Albalawi W, Fattaccioli A, Dieu M, Ruggiero A, McKeating JA, Ball JK, Tarr AW, Renard P, Pollakis G, and Paxton WA.

    Frontiers in Immunology (2022)

    See this work

  • Are the Patterns of Cytomegalovirus Viral Load Seen After Solid Organ Transplantation Affected by Circadian Rhythm?

    Rafferty H, Murray MJ, Tam JCH, Macfarlane A, Smith C, Lumley SF, Atabani S, McKeating JA, Sharma D, Reeves M, Whitmore D, and Griffiths P.

    Journal of Infectious Diseases (2022)

    See this work

  • Time of Day of Vaccination Affects SARS-CoV-2 Antibody Responses in an Observational Study of Health Care Workers.

    Wang W, Balfe P, Eyre DW, Lumley SF, O'Donnell D, Warren F, Crook DW, Jeffery K, Matthews PC, Klerman EB, and McKeating JA.

    Journal of Biological Rhythms (2022)

    See this work

2021

  • A Role for B Cells to Transmit Hepatitis C Virus Infection.

    Desombere I, Van Houtte F, Farhoudi A, Verhoye L, Buysschaert C, Gijbels Y, Couvent S, Swinnen W, Van Vlierberghe H, Elewaut A, Magri A, Stamataki Z, Meuleman P, McKeating JA, and Leroux-Roels G.

    Frontiers in Immunology (2021)

    See this work

  • An immunodominant NP105-113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease.

    Peng Y, Felce SL, Dong D, Penkava F, Mentzer AJ, Yao X, Liu G, Yin Z, Chen JL, Lu Y, Wellington D, Wing PAC, Dominey-Foy DCC, Jin C, Wang W, Hamid MA, Fernandes RA, Wang B, Fries A, Zhuang X, Ashley N, Rostron T, Waugh C, Sopp P, Hublitz P, Beveridge R, Tan TK, Dold C, Kwok AJ, Rich-Griffin C, Dejnirattisa W, Liu C, Kurupati P, Nassiri I, Watson RA, Tong O, Taylor CA, Kumar Sharma P, Sun B, Curion F, Revale S, Garner LC, Jansen K, Ferreira RC, Attar M, Fry JW, Russell RA; COMBAT Consortium, Stauss HJ, James W, Townsend A, Ho LP, Klenerman P, Mongkolsapaya J, Screaton GR, Dendrou C, Sansom SN, Bashford-Rogers R, Chain B, Smith GL, McKeating JA, Fairfax BP, Bowness P, McMichael AJ, Ogg G, Knight JC, and Dong T.

    Nature Immunology (2021)

    See this work

  • Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure.

    Smith DA, Fernandez-Antunez C, Magri A, Bowden R, Chaturvedi N, Fellay J, McLauchlan J, Foster GR, Irving WL; STOP-HCV Consortium, Simmonds P, Pedergnana V, Ramirez S, Bukh J, Barnes E, and Ansari MA.

    Nature Communications (2021)

    See this work

  • The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells.

    Zhuang X, Tsukuda S, Wrensch F, Wing PAC, Schilling M, Harris JM, Borrmann H, Morgan SB, Cane JL, Mailly L, Thakur N, Conceicao C, Sanghani H, Heydmann L, Bach C, Ashton A, Walsh S, Tan TK, Schimanski L, Huang KA, Schuster C, Watashi K, Hinks TSC, Jagannath A, Vausdevan SR, Bailey D, Baumert TF, and McKeating JA.

    iScience (2021)

    See this work

  • Hypoxia-Inducible Factor 1 Alpha-Mediated RelB/APOBEC3B Down-regulation Allows Hepatitis B Virus Persistence.

    Riedl T, Faure-Dupuy S, Rolland M, Schuehle S, Hizir Z, Calderazzo S, Zhuang X, Wettengel J, Lopez MA, Barnault R, Mirakaj V, Prokosch S, Heide D, Leuchtenberger C, Schneider M, Heßling B, Stottmeier B, Wessbecher IM, Schirmacher P, McKeating JA, Protzer U, Durantel D, Lucifora J, Dejardin E, and Heikenwalder M.

    Hepatology (2021)

    See this work

  • Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint.

    Schmidt NM, Wing PAC, Diniz MO, Pallett LJ, Swadling L, Harris JM, Burton AR, Jeffery-Smith A, Zakeri N, Amin OE, Kucykowicz S, Heemskerk MH, Davidson B, Meyer T, Grove J, Stauss HJ, Pineda-Torra I, Jolly C, Jury EC, McKeating JA, and Maini MK.

    Nature Communications (2021)

    See this work

  • Supramolecular Cylinders Target Bulge Structures in the 5' UTR of the RNA Genome of SARS-CoV-2 and Inhibit Viral Replication*.

    Melidis L, Hill HJ, Coltman NJ, Davies SP, Winczura K, Chauhan T, Craig JS, Garai A, Hooper CAJ, Egan RT, McKeating JA, Hodges NJ, Stamataki Z, Grzechnik P, and Hannon MJ.

    Angewandte Chemie International Edition (2021)

    See this work

  • Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells.

    Wing PAC, Keeley TP, Zhuang X, Lee JY, Prange-Barczynska M, Tsukuda S, Morgan SB, Harding AC, Argles ILA, Kurlekar S, Noerenberg M, Thompson CP, Huang KA, Balfe P, Watashi K, Castello A, Hinks TSC, James W, Ratcliffe PJ, Davis I, Hodson EJ, Bishop T, and McKeating JA.

    Cell Reports (2021)

    See this work

  • Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment.

    Ohashi H, Watashi K, Saso W, Shionoya K, Iwanami S, Hirokawa T, Shirai T, Kanaya S, Ito Y, Kim KS, Nomura T, Suzuki T, Nishioka K, Ando S, Ejima K, Koizumi Y, Tanaka T, Aoki S, Kuramochi K, Suzuki T, Hashiguchi T, Maenaka K, Matano T, Muramatsu M, Saijo M, Aihara K, Iwami S, Takeda M, McKeating JA, and Wakita T.

    iScience (2021)

    See this work

  • Estimating hepatitis B virus cccDNA persistence in chronic infection.

    Lythgoe KA, Lumley SF, Pellis L, McKeating JA, and Matthews PC.

    Virus Evolution (2021)

    See this work

  • Circadian control of hepatitis B virus replication.

    Zhuang X, Forde D, Tsukuda S, D'Arienzo V, Mailly L, Harris JM, Wing PAC, Borrmann H, Schilling M, Magri A, Rubio CO, Maidstone RJ, Iqbal M, Garzon M, Minisini R, Pirisi M, Butterworth S, Balfe P, Ray DW, Watashi K, Baumert TF, and McKeating JA.

    Nature Communications (2021)

    See this work

  • Hypoxia inducible factors regulate hepatitis B virus replication by activating the basal core promoter.

    Wing PAC, Liu PJ, Harris JM, Magri A, Michler T, Zhuang X, Borrmann H, Minisini R, Frampton NR, Wettengel JM, Mailly L, D'Arienzo V, Riedl T, Nobre L, Weekes MP, Pirisi M, Heikenwalder M, Baumert TF, Hammond EM, Mole DR, Protzer U, Balfe P, and McKeating JA.

    Journal of Hepatology (2021)

    See this work

  • Clocks, Viruses, and Immunity: Lessons for the COVID-19 Pandemic.

    Sengupta S, Ince L, Sartor F, Borrmann H, Zhuang X, Naik A, Curtis A, and McKeating JA.

    Journal of Biological Rhythms (2021)

    See this work

  • The Circadian Clock and Viral Infections.

    Borrmann H, McKeating JA, and Zhuang X.

    Journal of Biological Rhythms (2021)

    See this work

  • The CCCTC-binding factor CTCF represses hepatitis B virus enhancer I and regulates viral transcription.

    D'Arienzo V, Ferguson J, Giraud G, Chapus F, Harris JM, Wing PAC, Claydon A, Begum S, Zhuang X, Balfe P, Testoni B, McKeating JA, and Parish JL.

    Cellular Microbiology (2021)

    See this work

  • A PCR assay to quantify patterns of HBV transcription.

    D'Arienzo V, Magri A, Harris JM, Wing PAC, Ko C, Rubio CO, Revill PA, Protzer U, Balfe P, and McKeating JA.

    Journal of General Virology (2021)

    See this work

2020

  • Oxygen Sensing and Viral Replication: Implications for Tropism and Pathogenesis.

    Liu PJ, Balfe P, McKeating JA, and Schilling M.

    Viruses (2020)

    See this work

  • Cholesterol-modifying drugs in COVID-19.

    Schmidt NM, Wing PAC, McKeating JA, and Maini MK.

    Oxford Open Immunology (2020)

    See this work

  • Hypoxic gene expression in chronic hepatitis B virus infected patients is not observed in state-of-the-art in vitro and mouse infection models.

    Liu PJ, Harris JM, Marchi E, D'Arienzo V, Michler T, Wing PAC, Magri A, Ortega-Prieto AM, van de Klundert M, Wettengel J, Durantel D, Dorner M, Klenerman P, Protzer U, Giotis ES, and McKeating JA.

    Scientific Reports (2020)

    See this work

  • Synchronised infection identifies early rate-limiting steps in the hepatitis B virus life cycle.

    Chakraborty A, Ko C, Henning C, Lucko A, Harris JM, Chen F, Zhuang X, Wettengel JM, Roessler S, Protzer U, and McKeating JA.

    Cellular Microbiology (2020)

    See this work

  • Pharmacological activation of the circadian component REV-ERB inhibits HIV-1 replication.

    Borrmann H, Davies R, Dickinson M, Pedroza-Pacheco I, Schilling M, Vaughan-Jackson A, Magri A, James W, Balfe P, Borrow P, McKeating JA, and Zhuang X.

    Scientific Reports (2020)

    See this work

  • Hypoxic microenvironment shapes HIV-1 replication and latency.

    Zhuang X, Pedroza-Pacheco I, Nawroth I, Kliszczak AE, Magri A, Paes W, Rubio CO, Yang H, Ashcroft M, Mole D, Balfe P, Borrow P, and McKeating JA.

    Communications Biology (2020)

    See this work

  • Accurate targeted long-read DNA methylation and hydroxymethylation sequencing with TAPS.

    Liu Y, Cheng J, Siejka-Zielińska P, Weldon C, Roberts H, Lopopolo M, Magri A, D'Arienzo V, Harris JM, McKeating JA, and Song CX.

    Genomes Biology (2020)

    See this work

  • Cost-Effectiveness Analysis of Baseline Testing for Resistance-Associated Polymorphisms to Optimize Treatment Outcome in Genotype 1 Noncirrhotic Treatment-Naïve Patients With Chronic Hepatitis C Virus.

    Fawsitt CG, Vickerman P, Cooke GS; STOP HCV Consortium, and Welton NJ.

    Value in Health (2020)

    See this work

2019

  • Bacterial flagellin promotes viral entry via an NF-kB and Toll Like Receptor 5 dependent pathway.

    Benedikz EK, Bailey D, Cook CNL, Gonçalves-Carneiro D, Buckner MMC, Blair JMA, Wells TJ, Fletcher NF, Goodall M, Flores-Langarica A, Kingsley RA, Madsen J, Teeling J, Johnston SL, MacLennan CA, Balfe P, Henderson IR, Piddock LJV, Cunningham AF, and McKeating JA.

    Scientific Reports (2019)

    See this work

  • A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis.

    Wing PA, Davenne T, Wettengel J, Lai AG, Zhuang X, Chakraborty A, D'Arienzo V, Kramer C, Ko C, Harris JM, Schreiner S, Higgs M, Roessler S, Parish JL, Protzer U, Balfe P, Rehwinkel J, and McKeating JA.

    Life Science Alliance (2019)

    See this work

  • The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication.

    Zhuang X, Magri A, Hill M, Lai AG, Kumar A, Rambhatla SB, Donald CL, Lopez-Clavijo AF, Rudge S, Pinnick K, Chang WH, Wing PAC, Brown R, Qin X, Simmonds P, Baumert TF, Ray D, Loudon A, Balfe P, Wakelam M, Butterworth S, Kohl A, Jopling CL, Zitzmann N, and McKeating JA.

    Nature Communications (2019)

    See this work

  • Hepatitis C virus infection is associated with hepatic and adipose tissue insulin resistance that improves after viral cure.

    Lim TR, Hazlehurst JM, Oprescu AI, Armstrong MJ, Abdullah SF, Davies NP, Flintham R, Balfe P, Mutimer DJ, McKeating JA, and Tomlinson JW.

    Clinical Endocrinology (2019)

    See this work

  • Insights From Deep Sequencing of the HBV Genome-Unique, Tiny, and Misunderstood.

    McNaughton AL, D'Arienzo V, Ansari MA, Lumley SF, Littlejohn M, Revill P, McKeating JA, and Matthews PC.

    Gastroenterology (2019)

    See this work

2018

  • Glucose and glutamine availability regulate HepG2 transcriptional responses to low oxygen.

    Lai AG, Forde D, Chang WH, Yuan F, Zhuang X, Orbegozo Rubio C, Song CX, and McKeating JA.

    Wellcome Open Research (2018)

    See this work

  • Daytime variation in hepatitis C virus replication kinetics following liver transplant.

    Zhuang X, Lai AG, McKeating JA, Rowe I, and Balfe P.

    Wellcome Open Research (2019)

    See this work

  • Metallo supramolecular cylinders inhibit HIV-1 TAR-TAT complex formation and viral replication in cellulo.

    Cardo L, Nawroth I, Cail PJ, McKeating JA, and Hannon MJ.

    Scientific Reports (2019)

    See this work

  • Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels.

    Ko C, Chakraborty A, Chou WM, Hasreiter J, Wettengel JM, Stadler D, Bester R, Asen T, Zhang K, Wisskirchen K, McKeating JA, Ryu WS, and Protzer U.

    Hepatology (2019)

    See this work

Key Earlier Publications

  • Complete Replication of Hepatitis C Virus in Cell Culture

    Lindenbach BD, Evans MJ, Syder AJ, Wölk B, Tellinghuisen TL, Liu CC, Maruyama T, Hynes RO, Burton DR, McKeating JA, and Rice CM.

    Science (2005)

    See this work

  • Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication

    Blight KJ, McKeating JA, and Rice CM.

    Journal of Virology (2002)

    See this work

  • Claudin Association with CD81 Defines Hepatitis C Virus Entry

    Harris HJ, Davis C, Mullins JGL, Hu K, Goodall M, Farquhar MJ, Mee CJ, McCaffrey K, Young S, Drummer H, Balfe P, and McKeating JA.

    Journal of Biological Chemistry (2010)

    See this work

  • Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry

    Evans MJ, von Hahn T, Tscherne DM, Syder AJ, Panis M, Wölk B, Hatziioannou T, McKeating JA, Bieniasz PD, and Rice CM.

    Nature (2007)

    See this work

  • Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles

    Hsu M, Zhang J, Flint M, Logvinoff C, Cheng-Mayer C, Rice CM, and McKeating JA.

    Proceedings of the Natural Academy of Sciences (2003)

    See this work

  • Neutralizing antibody response during acute and chronic hepatitis C virus infection

    Logvinoff C, Major ME, Oldach D, Heyward S, Talal A, Balfe P, Feinstone SM, Alter H, Rice CM, and McKeating JA.

    Proceedings of the National Academy of Sciences (2004)

    See this work

  • Hepatitis C Virus Continuously Escapes From Neutralizing Antibody and T-Cell Responses During Chronic Infection In Vivo

    von Hahn T, Yoon JC, Alter H, Rice CM, Rehermann B, Balfe P, and McKeating JA.

    Gastroenterology (2007)

    See this work

  • Hepatitis C virus cell-cell transmission in hepatoma cells in the presence of neutralizing antibodies

    Timpe JM, Stamataki Z, Jennings A, Hu K, Farquhar MJ, Harris HJ, Schwarz A, Desombere I, Roels GL, Balfe P, and McKeating JA.

    Hepatology (2008)

    See this work

  • EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy

    Lupberger J, Zeisel MB, Xiao F, Thumann C, Fofana I, Zona L, Davis C, Mee CJ, Turek M, Gorke S, Royer C, Fischer B, Zahid MN, Lavillette D, Fresquet J, Cosset F-L, Rothenberg SM, Pietschmann T, Patel AH, Pessaux P, Doffoël M, Raffelsberger W, Poch O, McKeating JA, Brino L, and Baumert TF.

    Nature Medicine (2011)

    See this work

  • Hepatitis C Virus Infects the Endothelial Cells of the Blood-Brain Barrier

    Fletcher NF, Wilson GK, Murray J, Hu K, Lewis A, Reynolds GM, Stamataki Z, Meredith LW, Rowe IA, Luo G, Lopez–Ramirez MA, Baumert TF, Weksler Babette, Couraud P-O, Kim KS, Romero IA, Jopling C, Morgello S, Balfe P, and McKeating JA.

    Gastroenterology (2012)

    See this work

  • HIV susceptibility conferred to human fibroblasts by cytomegalovirus-induced Fc receptor

    McKeating JA, Griffiths PD, and Weiss RA.

    Nature (1990)

    See this work

  • Dissociation of gp120 from HIV-1 virions induced by soluble CD4

    Moore J, McKeating JA, Weiss R, and Sattentau Q.

    Science (1990)

    See this work